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Oral metronidazole continues to be documented to potentiate the anticoagulant result of warfarin as well as other coumarin anti‑coagulants, resulting in a prolongation of prothrombin time.
Metronidazole has shown evidence of carcinogenic action in quite a few studies involving Serious oral administration in mice and rats. Well known among the the results while in the mouse was the promotion of pulmonary tumorigenesis. This has become observed in all six described experiments in that species, including just one study wherein the animals have been dosed on an intermittent schedule (administration through each and every fourth week only). At incredibly significant dose concentrations (around five hundred mg/kg/working day), there was a statistically major increase in the incidence of malignant liver tumors in males.
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